What is Cholesterol?

Cholesterol is a sterol (a combination steroid and alcohol). Cholesterol is a lipid found in the cell membranes of all tissues, and it is transported in the blood plasma of all animals. Because cholesterol is synthesized by all eukaryotes, trace amounts of cholesterol are also found in membranes of plants and fungi.The name originates from the Greek chole- (bile) and stereos (solid), and the chemical suffix -ol for an alcohol, as researchers first identified cholesterol in solid form in gallstones by Francois Poulletier de la Salle in 1769. However, it is only in 1815 that chemist Eugene Chevreul named the compound "cholesterine".[2]Most of the cholesterol is synthesized by the body and some has dietary origin. Cholesterol is more abundant in tissues which either synthesize more or have more abundant densely-packed membranes, for example, the liver, spinal cord and brain. It plays a central role in many biochemical processes, such as the composition of cell membranes and the synthesis of steroid hormones. Cholesterol is insoluble in blood, but is transported in the circulatory system bound to one of the varieties of lipoprotein, spherical particles which have an exterior composed mainly of water-soluble proteins. The main types, low-density lipoprotein (LDL) and high-density lipoprotein (HDL) carry cholesterol from and to the liver.According to the lipid hypothesis, abnormally high cholesterol levels (hypercholesterolemia) and abnormal proportions of LDL and HDL are associated with cardiovascular disease by promoting atheroma development in arteries (atherosclerosis). This disease process leads to myocardial infarction (heart attack), stroke and peripheral vascular disease. As high LDL contributes to this process, it is termed "bad cholesterol", while high levels of HDL ("good cholesterol") offer a degree of protection. The balance can be redressed with exercise, a healthy diet, and sometimes medication.

blood pressure variation
Diurnal Blood Pressure Variation in Progressive Autonomic Failure
Abstractâ”To investigate the role of the autonomic nervous system (ANS) in the generation of the circadian blood pressure (BP) variation, the degree of

Sao Paulo Medical Journal - Seasonal variation of blood pressure
Seasonal blood pressure variation is observed in all age groups7,8 and, at least for patients with hypertension, this variation is higher in older than in

Determinants of Circadian Blood Pressure Variation: A Community
We investigated facters affecting the nocturnal decline in blood pressure (BP). A cross sectional study was done in 706 community-based untreated subjects

SPC Guide
Over the next several years, I monitored my blood pressure as I experimented with ways to bring it down. In Figure 1, The R chart indicates the variation

Molecular genetics of human blood pressure variation.
These findings demonstrate the utility of molecular genetic approaches to the understanding of blood pressure variation and may provide insight into the

Blood pressure variation in blacks: genetic factors.
Blood pressure variation in blacks: genetic factors. Grim CE, Robinson M. Department of Cardiovascular Medicine, Medical College of Wisconsin, Milwaukee,

Diurnal blood pressure variation and albuminuria in normotensive
Key words: diabetes mellitus; diabetic nephropathy; microalbuminuria; blood pressure; circadian variation; blood pressure load

Arch Intern Med -- Abstract: Association of Impaired Diurnal Blood
Conclusion Blunted diurnal blood pressure variation is associated with a subsequent deterioration in renal function that is independent of SBP load and

ScienceDirect - American Journal of Hypertension : Blood pressure
The purpose of this study was to clarify the relationship between blood pressure variation and urinary catecholamines in centenarian people.

Circadian Blood Pressure Variation and Antihypertensive Medication
Background/Aims: The aim of the study was to assess the effect of an antihypertensive treatment adjustment on 24-hour blood pressure variation in type 2

IngentaConnect Blood pressure variation among Ethiopians on the
This report presents information on determinants of blood pressure variation in a rural sample of 263 Ethiopian highlanders 14â“86 years of age,

Day-night blood pressure variation in normotensive
OBJECTIVE--To examine day-night blood pressure (BP) variation in normotensive, normoalbuminuric subjects with type I diabetes and to assess the prevalence

Diurnal and Short-Term Variation of Blood Pressure: Comparison of
In the clinical management of patients, these findings are significant, as they demonstrate short-term variation in blood pressure and differences in the

American Journal of Hypertension - Impaired Diurnal Blood Pressure
Table 3 - Impaired diurnal blood pressure variation as a predictor of death. Diurnal variation of blood pressure in elderly patients with essential

Why Studying Blood Pressure is a Challenge
Because so many intermediate systems and traits contribute to blood pressure determination, variation in a large number of genes can potentially influence

Journal of Hypertension - Abstract: Volume 21(11) November 2003 p
A comparison of awake-sleep blood pressure variation between normotensive Objective: To compare awake-sleep ambulatory blood pressure variation between

Normal diurnal variation in pressure with a nocturnal dip
24 hour ambulatory blood pressure profile showing a nocturnal dip in a In most individuals blood pressure falls by 10 - 20% during the night.

Wide Blood Pressure Variation Between Arms
A patient with left carotid endarterectomy presented an unrelated complaint of posterior neck pain.

Blood pressure measurement
The information is recorded on a chip in the device and allows the doctor to get a detailed picture of blood pressure variation in a normal environment.


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